Clinical Outcomes and Learning Curve of Endoscopic Ultrasound‐Guided Hepaticogastrostomy During the Implementation Phase in Inexperienced Centers: A Multicenter Retrospective Study

ABSTRACT Objectives Endoscopic ultrasound‐guided hepaticogastrostomy (EUS‐HGS) is a technically demanding procedure performed predominantly at centers with high expertise. Its feasibility and learning curves in inexperienced centers remain unclear. This study aimed to evaluate the initial clinical outcomes and learning curves of EUS‐HGS implemented in inexperienced centers. Methods Between September 2018 and December 2020, four tertiary care centers specializing in pancreaticobiliary disease implemented EUS‐HGS. The first 20 patients who underwent EUS‐HGS at each institution were retrospectively enrolled. The primary outcomes were technical success, procedure time, and serious (moderate‐to‐severe) adverse events (AEs). A learning curve analysis was conducted using chronological quartiles. Logistic regression was used to identify the predictors of technical failure and serious AEs. Results The overall technical success rate was 94% (75/80); serious AEs occurred in 11% (9/80). Procedure time significantly decreased across quartiles, whereas no significant trend was observed for technical success or serious AE rates. The univariate analysis did not identify significant predictors of technical failure, whereas the multivariate analysis identified ascites as an independent predictor of serious AEs. Conclusions EUS‐HGS can be feasibly implemented with caution in inexperienced centers, particularly when performed by endoscopists with adequate pancreatobiliary expertise. Additionally, during the implementation phase, procedure time decreased with increasing institutional experience.