PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
February 2, 2026Cardiovascular DiabetologyOpen Access

A 5-hydroxymethylcytosine-based noninvasive model for acute myocardial infarction in type 2 diabetes: implications in cardiovascular outcomes from a 5-year median follow-up study

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does a 5hmC-derived weighted epigenetic score (eSCORE-CARD) predict composite cardiovascular outcomes in patients with type 2 diabetes?

Population

171 patients with type 2 diabetes, mean age 62.7, 56.7% male, from China. Exclusions: severe heart failure…

Comparison

5hmC-derived weighted epigenetic score based on… vs Low eSCORE-CARD values or T2D patients without AMI

Design

Cohort

Follow-up

median 5.3 years

Key result

A 5hmC-derived weighted epigenetic score (eSCORE-CARD) was significantly associated with an increased risk of composite cardiovascular outcomes (HR 4.25) in patients with type 2 diabetes.

Authors

KYKun YangSQShanshan QinSXShaohua Xu

Discussion

Loading...

Member takes

Overview

May refine AMI risk stratification in T2D; extends 5hmC epigenetic biomarker research to cardiovascular outcomes.

Key Points

  • The research aims to identify specific biomarkers related to acute myocardial infarction in individuals with type 2 diabetes.
  • Identified 5-hydroxymethylcytosine (5hmC) signatures in patients with type 2 diabetes.
  • Conducted a 5-year follow-up to assess cardiovascular outcomes.
  • Developed a risk management tool based on observed biomarkers.
  • Found specific 5hmC signatures associated with acute myocardial infarction in type 2 diabetes.
  • Demonstrated potential for improved cardiovascular risk management in the diabetic population.

Study Design

Type

Cohort (n=171)

Multicenter

No

Structured PICO

Does a 5hmC-derived weighted epigenetic score (eSCORE-CARD) predict composite cardiovascular outcomes in patients with type 2 diabetes?

P
Population
171 patients with type 2 diabetes, with or without acute myocardial infarction, followed for a median of 5.3 years to assess cardiovascular outcomes.
E
Exposure
5hmC-derived weighted epigenetic score (eSCORE-CARD) based on circulating cell-free DNA
C
Comparator
Low eSCORE-CARD values or T2D patients without AMI
O
Outcome
Composite cardiovascular outcome (CCO), defined as the time to cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or hospitalization for heart failure over a median follow-up of 5.3 yearscomposite

Main Result

Hazard Ratio: 4.25 (95% CI 1.41–12.8)

p-value: p=<0.05

Cite This Study

Yang et al. (2026) conducted a cohort in Type 2 diabetes with or without acute myocardial infarction (n=171). eSCORE-CARD (5hmC-derived weighted epigenetic score) vs. Low eSCORE-CARD score was evaluated on Composite cardiovascular outcomes (CCO) (HR 4.25, 95% CI 1.41-12.80, p=<0.05). A 5hmC-derived weighted epigenetic score (eSCORE-CARD) was significantly associated with an increased risk of composite cardiovascular outcomes (HR 4.25) in patients with type 2 diabetes.

synapsesocial.com/papers/6980fde8c1c9540dea80f8cbhttps://doi.org/10.1186/s12933-026-03087-2
View Full Paper
Ask AI
Bookmark
Share