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Synapse
February 2, 20260 citations

Prognostic Factors and the Impact of Adjuvant S-1 Chemotherapy in Resected Ampulla of Vater Carcinoma: A Single-institution Retrospective Study.

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HIHAJIME IMAMURATATomohiko AdachiTHTakashi Hamada

Key Points

  • The aim is to evaluate prognosis and the effectiveness of S-1 chemotherapy in patients with resected ampullary carcinoma.
  • Retrospective study design
  • Assessment of lymph node status
  • Evaluation of survival outcomes with adjuvant S-1 chemotherapy
  • Lymph node status is identified as a key prognostic factor.
  • Adjuvant S-1 chemotherapy shows no significant survival improvement for node-positive patients.
  • Findings highlight the necessity for developing more effective adjuvant treatments.

Abstract

Lymph node status is a major prognostic factor in ampullary carcinoma. Adjuvant S-1 chemotherapy conferred no significant survival benefit for node-positive patients, underscoring the need for more effective adjuvant strategies.

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Cite This Study

IMAMURA et al. (2026) studied this question.

synapsesocial.com/papers/6980fe35c1c9540dea8100c7https://doi.org/10.21873/anticanres.17993
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advanced Adenosquamous Carcinoma of the Ampulla of Vater Treated with Adjuvant Chemotherapy after Pancreaticoduodenectomy2024
  2. 2Clinicopathologic Analysis and Prognostic Factors for Survival in Patients with Operable Ampullary Carcinoma: A Multi-Institutional Retrospective Experience2024
  3. 3Prognostic Efficacy of Lymph Node Parameters in Resected Ampullary Adenocarcinoma Based on Long-term Follow-Up Data after Adjuvant Treatment2024
  4. 4Is Adjuvant Chemotherapy Necessary for Stage IIB/IIC Appendiceal Adenocarcinoma?2026
  5. 5Ampullary Carcinoma: Prognostic Factors and a Literature Review2026