The present study aimed to develop and evaluate chitosan-based mucoadhesive microspheres of rebamipide for sustained gastric drug delivery. Rebamipide-loaded microspheres were prepared using the ionotropic gelation method with sodium tripolyphosphate as a crosslinking agent. Preformulation studies confirmed the identity, purity, and suitability of the drug for formulation development. Six formulations were developed by varying polymer and crosslinker concentrations. The optimized formulation (F3) showed the highest percentage yield (76.65 ± 0.74%) and entrapment efficiency (76.65 ± 0.25%). Particle size analysis revealed nanosized microspheres (225.65 nm) with good stability, as indicated by a zeta potential of −35.65 mV. In vitro release studies demonstrated sustained drug release (98.12% over 12 h) compared to the plain drug. Release kinetics followed zero-order and Korsmeyer–Peppas models, indicating a non-Fickian diffusion mechanism. The results suggest that chitosan-based mucoadhesive microspheres are a promising system for improving the oral delivery of rebamipide.
Rituja Dharpure*, Shailendra Prasad Tiwari, Deepak Basedia, B K Dubey, Sunil K Shah and Mukesh Patel (Sun,) studied this question.
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