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February 2, 2026Immunological Reviews

Sex Differences in Alloimmunity and Other Immunological Considerations in Organ Transplantation

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Authors

WPWhitney PerryPSPritha Sen

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Overview

Reports sex-based differences in immune responses affecting transplant outcomes, suggesting a need for tailored immunosuppressive strategies.

Key Points

  • The aim is to explore sex-specific differences in immune responses related to organ transplantation and their implications for clinical outcomes.
  • Reviewed existing literature on sex differences in immunity within the context of transplantation.
  • Analyzed how chromosomal and hormonal variations impact immune function in transplant recipients.
  • Investigated the effects of age on sex differences in transplant outcomes and infection risks.
  • Young females show a higher risk for poor transplant outcomes due to alloimmunity compared to similarly-aged males.
  • Post-menopausal women may face increased risks for transplant-related infections.
  • Highlighting the importance of incorporating sex as a biological variable can enhance transplant care.

Cite This Study

Perry et al. (2026) studied this question.

synapsesocial.com/papers/6980fe48c1c9540dea810377https://doi.org/10.1111/imr.70104
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sex Disparities in Transplantation Access and Outcomes: An Overview2026 · 2 citations
  2. 2Sex- and Age-based Comparison of Key Clinical Markers of Immunity After Heart and Kidney Transplantation2025 · 1 citations
  3. 3Older Kidney Transplant Patients Are Over Immunosuppressed Using Standard Protocols With Differential Sex‐Based Complications2025 · 3 citations
  4. 4Gender and kidney transplantation2024 · 5 citations
  5. 5Sexual Dimorphism in Renal Progenitors: Do Immunosuppressants Erase the Female Advantage?2026