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February 2, 2026Gut MicrobesOpen Access

Akkermansia muciniphila 's nifJ gene enhances colostrum sIgA synthesis by branched-chain amino acid degradation to branched short-chain fatty acids

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Authors

DWDeyuan WuFLFuyong LiWXWenyu Xiong

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Overview

Experimental investigation shows Akkermansia muciniphila enhances sIgA synthesis in colostrum, indicating important gut-mammary axis communication.

Key Points

  • The study aims to explore how Akkermansia muciniphila influences sIgA synthesis in colostrum through amino acid metabolism.
  • Used mice models to analyze the effects of Akkermansia muciniphila's nifJ gene.
  • Measured sIgA levels in sow colostrum and associated them with gut microbial composition.
  • Investigated the metabolic pathway of branched-chain amino acids leading to short-chain fatty acids.
  • Colostrum sIgA levels correlate with increased Akkermansia muciniphila and branched-chain amino acid metabolism.
  • NifJ gene mediates the conversion of branched-chain amino acids into short-chain fatty acids.
  • Enhanced short-chain fatty acids upregulate TGF-β and CCL28 in mammary tissues, boosting sIgA synthesis.

Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/6980fe57c1c9540dea8104fahttps://doi.org/10.1080/19490976.2026.2620128
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