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February 2, 2026EndocrinologyOpen Access

Selenoprotein P deletion ameliorates metabolic stress-associated anxiety-like behavior in male mice

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Authors

GGGuzel GafiyatullinaASAnna A. ShabalovaHGHisanori Goto

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Overview

Mouse models demonstrate that deleting selenoprotein P reduces anxiety linked to metabolic stress, suggesting new therapeutic avenues.

Key Points

  • The study aims to clarify the relationship between selenoprotein P and anxiety triggered by metabolic stress.
  • Visualized Selenop expression in mouse brain using RNAscope in situ hybridization.
  • Evaluated gene expression in brain regions via RT-qPCR.
  • Created brain-specific Selenop knockout mice by breeding specific mouse strains.
  • Conducted behavior tests for anxiety-like behavior under standard and high-fat, high-sucrose diet conditions.
  • Examined serum selenoprotein P concentrations in a general population cohort study.
  • Identified glial and endothelial cells as sources of SeP synthesis in the brain.
  • No changes in body weight or glucose tolerance in knockout mice on a high-fat diet.
  • High-fat, high-sucrose diet increased anxiety-like behavior in control mice.
  • Brain-specific deletion of Selenop reduced anxiety-like behavior without affecting spatial memory.
  • Epidemiological data showed higher serum selenoprotein P levels in individuals with anxiety symptoms.

Cite This Study

Gafiyatullina et al. (2026) studied this question.

synapsesocial.com/papers/6980fed9c1c9540dea8113fbhttps://doi.org/10.1210/endocr/bqag010
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