Evaluation of Anti-inflammatory Effects of Metformin and Dapagliflozin in a Complete Freund’s Adjuvant-induced Arthritis Model in Streptozotocin-induced Diabetic Rats
Evaluates anti-inflammatory effects in diabetic rats using metformin and dapagliflozin, indicating potential therapeutic benefits.
Key Points
The research aims to assess the effects of diabetes on chronic inflammation and investigate the anti-inflammatory effects of metformin and dapagliflozin in a rat model.
Induced diabetes in male Wistar rats using streptozotocin.
Modeled chronic inflammation with complete Freund’s adjuvant injection in the right hind paw.
Administered metformin, dapagliflozin, or their combination for 28 days.
Measured paw edema at defined intervals and analyzed ankle joints histopathologically.
Conducted statistical analysis using one-way ANOVA and Tukey’s post hoc test.
Diabetic rats showed significantly increased inflammation compared to normal controls.
All treatments significantly reduced inflammation levels.
Combination therapy compared favorably to monotherapy and aspirin in reducing inflammation.