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February 2, 2026International Journal of Social Psychiatry

Mental Pain and Psychological Correlates in Individuals With Gender Dysphoria

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Authors

MFMarco FaldiLTLivio TarchiECEmanuele Cassioli

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Overview

Case-control study assesses mental pain levels and psychological correlates in individuals with gender dysphoria, suggesting implications for treatment.

Key Points

  • This research aims to evaluate mental pain levels in individuals with gender dysphoria compared to a control group and identify psychological factors associated with it.
  • Conducted a case-control study with 180 individuals (94 with GD, 86 controls)
  • Participants completed various questionnaires assessing mental pain and psychological conditions
  • Assessed differences in mental pain based on gender affirming hormone therapy status
  • Individuals with GD reported significantly higher mental pain compared to controls (Cohen’s d = 0.318, p < 0.001)
  • Positive correlations found between mental pain and factors like general mental distress (r = .559, p < .001) and depression (r = .828, p < .001)
  • Those undergoing gender affirming hormone therapy for over a year reported lower mental pain levels (Cohen’s d = 0.571, p < 0.001)

Cite This Study

Faldi et al. (2026) studied this question.

synapsesocial.com/papers/6980ffb4c1c9540dea812778https://doi.org/10.1177/00207640251409842
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