PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
February 2, 2026Cell Communication and Signaling2 citationsOpen Access

Annexin A2-dependent extracellular vesicle proteome modulates pre-metastatic stromal fibroblast behavior in triple-negative breast cancer

View Full Paper
RTRucha TrivediPRPayal RanadeKTK. T. Tchedre

Key Points

  • The study aims to understand how annexin A2 affects the composition of extracellular vesicles and their role in fibroblast behavior in triple-negative breast cancer.
  • Analyzed the protein composition of extracellular vesicles derived from triple-negative breast cancer (TNBC) cells.
  • Studied interactions between TNBC-derived EVs and lung fibroblasts.
  • Examined effects on fibroblast motility and activation in the presence of EVs.
  • Annexin A2 positively regulates the protein composition of TNBC-derived extracellular vesicles.
  • EVs enhance interactions with lung fibroblasts, promoting fibroblast motility.
  • Findings suggest that EVs influence stromal remodeling in the lung environment, aiding metastasis.

Abstract

AnxA2 emerges as a regulator of the protein composition of TNBC-derived EVs, enhancing EV-mediated interactions with lung fibroblasts and modulating fibroblast motility and activation, linking tumor cell protein expression to stromal remodeling in the lung microenvironment. This work establishes a framework suggestive of an EV cargo-driven mechanism through which EVs derived from AnxA2-expressing cells may influence lung-specific metastatic colonization in TNBC and highlights the importance of evaluating EV-mediated communication in cancer progression.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Trivedi et al. (2026) studied this question.

synapsesocial.com/papers/6980ffc6c1c9540dea81279ehttps://doi.org/10.1186/s12964-026-02708-3
Ask AI
Helpful
Bookmark
Share
View Full Paper