Abstract:: The review provides a comprehensive overview of the latest methodologies developed for the synthesis of kavalactones, a class of bioactive compounds derived from the root of kava (Piper methysticum, Piperaceae). The review focuses on summarizing various synthetic strategies reported in the literature from 1995 to 2025, highlighting their advantages, limitations, and potential for scalability. It discusses the diverse approaches for synthesizing kavalactones, including the use of different starting materials, reagents, and conditions to achieve high-yielding, cost-effective, and environmentally friendly outcomes. By comparing these methods, the review identifies the most practical and efficient strategies currently available. It suggests areas where future research could lead to improved synthetic strategies to optimize kavalactone synthesis further. Through this comprehensive overview, the manuscript provides valuable insights for researchers aiming to develop superior synthetic methods for kavalactones.
Balasubramanian et al. (2026) studied this question.