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February 2, 2026Scientific ReportsOpen Access

Oxidative stress-associated genes TPPP3 and VEGFA in COPD revealed by bulk and single-cell sequencing analysis

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Authors

WCWenglam ChoiYWYelin WuWCWenjing CHEN

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Overview

Identifies key oxidative stress genes in COPD, highlighting their diagnostic and therapeutic potential.

Key Points

  • The study aims to identify oxidative stress-related genes and pathways involved in COPD through bioinformatics and experimental validation.
  • Analyzed public COPD datasets from the GEO database.
  • Retrieved oxidative stress-related genes from the GeneCards database.
  • Used machine-learning algorithms to identify hub genes and evaluate diagnostic value.
  • Conducted single-cell RNA sequencing analysis to assess gene distribution across cell types.
  • Established a COPD oxidative stress cell model for experimental validation.
  • Identified 76 genes associated with both COPD and oxidative stress.
  • Screened 12 hub genes using machine-learning methods.
  • Found TPPP3 and VEGFA mainly expressed in epithelial cells.
  • Validated gene expression predictions experimentally.

Cite This Study

Choi et al. (2026) studied this question.

synapsesocial.com/papers/6980fff5c1c9540dea812db6https://doi.org/10.1038/s41598-026-37375-4
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