The convergence of the Internet of Everything (IoE) and healthcare requires ultra-reliable, low-latency, and intelligent communication systems. Sixth-generation (6G) wireless networks, coupled with digital twin (DT) models and large AI models (LAMs), are envisioned to promise substantial and practically meaningful improvements in smart healthcare by enabling real-time monitoring, diagnosis, and personalized treatment. In this article, we propose an LAM-enhanced DT-driven network slicing framework for healthcare applications. The framework leverages large models to provide predictive insights and adaptive orchestration by creating virtual replicas of patients and medical devices that guide dynamic slice allocation. Reinforcement learning (RL) techniques are employed to optimize slice orchestration under uncertain traffic conditions, with LAMs augmenting decision-making through cognitive-level reasoning. Numerical results show that the proposed LAM–DT–RL framework reduces service-level agreement (SLA) violations by approximately 42–43% compared to a reinforcement-learning-only slicing strategy, while improving spectral efficiency and fairness among heterogeneous healthcare services. Finally, we outline open challenges and future research opportunities in integrating LAMs, DTs, and 6G for resilient healthcare IoE systems.
Hu et al. (2026) studied this question.