Background and Aim: Oral squamous cell carcinoma (OSCC) is the most common oral malignant tumor. Identification of histopathological parameters leads to accurate prognosis and appropriate treatment plans. Comparative evaluation of some histopathological parameters of OSCC with and without cervical lymph nodes (CLNs) metastasis is the aim of this study. Materials and Methods: In this cross-sectional study, 20 OSCCs with CLNs metastasis (group1) and 20 samples without CLNs metastasis (group 2) who underwent excisional biopsy with neck dissection from the archives of Pathology Department of Kashani Hospital, Isfahan were included. Clinical information such as age, gender and site of tumor were extracted. Hematoxylin and eosin–stained sections were reviewed with light microscope by two blinded oral pathologists and some histopathological parameters such as pattern of invasion, histopathologic grade, CLNs metastasis, tumor budding and host lymphocytic response were determined. All data was entered into SPSS24 software and was analyzed by Mann-Whitney, Chi-Square, T and the Fisher exact tests. P value <0/05 was considered as a significant difference. Results: Significant difference was found between two groups based on the tumor stage, tumor budding (p<0.001) and pattern of invasion (p=0.025). But no significant difference was found based on the tumor dimensions (p=0.086), age (p=0.59), gender (p=0.206), location (p=0.407), infiltration of inflammatory cells (p=0.8) and histopathologic grade (p=0.98) between two groups. Conclusion: Histopathological parameters can be used as prognostic indicators and effective factors in determining the treatment plan of patients.
Khalesi et al. (Wed,) studied this question.