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February 3, 2026Advanced Science0 citationsOpen Access

Unique Aerofoil‐Structured Microfluidics for High Throughput Lipid Nanoparticle Formulation Screening and Scale‐up (Adv. Sci. 6/2026)

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DLDongsheng LiuMYMingzhi YuYZYuguo Zhang

Key Points

  • To explore the impact of aerofoil-structured microfluidics on lipid nanoparticle formulation and scaling.
  • Employs microfluidic technology with aerofoil structures
  • Integrates hydrophilic and hydrophobic domains for enhanced wetting
  • Utilizes in situ visualization to observe processes
  • Improves mass transport through porous transport layers
  • Achieves stable electrolysis in membrane electrode assemblies
  • Reduces gas accumulation and facilitates continuous bubble release

Abstract

Synergistic wetting, achieved by integrating hydrophilic and hydrophobic domains, enhances mass transport in porous transport layers. In situ visualization reveals that dual-phase wetting suppresses gas accumulation and promotes continuous bubble release, enabling stable, bubble-free electrolysis within membrane electrode assemblies. This simple yet powerful strategy overcomes transport limitations and advances porous transport layer design for efficient gas/liquid diffusion.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6981456cf607237d8b54d45chttps://doi.org/10.1002/advs.73653
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