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February 3, 2026Microbial Cell FactoriesOpen Access

Model-driven exploration of lactose and galactose metabolism via an oxidoreductive pathway in Sungouiella intermedia for cell factory applications

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Authors

KPKameshwara V. R. PeriIDIván DomenzainHAHanna Alalam

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Overview

Model demonstrates galactitol production in Sungouiella intermedia via strain engineering, indicating potential for industrial applications.

Key Points

  • This research aims to explore the lactose and galactose metabolism in Sungouiella intermedia for bioprocess applications.
  • Investigated metabolic pathways of S. intermedia using genome-scale metabolic model (GEM) and experimental analysis.
  • Employed continuous and batch bioreactors for testing metabolic processes.
  • Analyzed transcriptomic data and metabolite outputs to assess metabolic capabilities.
  • Conducted strain engineering to enhance galactitol production.
  • S. intermedia exhibits a dominant Leloir pathway for galactose metabolism alongside the oxidoreductive pathway.
  • Galactitol was produced as a carbon overflow metabolite, facilitating redox balance during growth.
  • Strain engineering led to > 90% galactitol yields from cheese whey permeate feedstock.
  • Engineered strains showed capability for converting galactitol to tagatose, showcasing versatility.

Cite This Study

Peri et al. (2026) studied this question.

synapsesocial.com/papers/6981456cf607237d8b54d48bhttps://doi.org/10.1186/s12934-026-02941-y
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