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February 5, 2026International Psychogeriatrics0 citationsOpen Access

Potentially inappropriate medications and treatment adherence in older adults with depressive disorder: A population-based cohort study

DIDiego Infante-VenturaBRBenjamin Rodriguez-DíazALAlejandra Abrante Luis

Key Points

  • This study aims to examine the prevalence of potentially inappropriate medications (PIM) and its impact on treatment adherence in older adults with depressive disorder.
  • Population-based cohort study design
  • Analysis of medication prescriptions
  • Focus on older adults with depressive disorder
  • Comparison between demographics and comorbidities
  • High prevalence of PIM prescriptions identified in older adults with depression
  • Younger older adults and women showed higher risks for receiving PIM
  • Psychiatric or nursing comorbidities linked to increased PIM prescription rates
  • Concerns raised regarding the potential effect of PIM on treatment adherence

Abstract

The findings here indicate a worrying prevalence of PIM prescription in this population. A higher risk of receiving a PIM was observed in comparatively younger older adults, women, and those with psychiatric or nursing comorbidities, with potential implications for treatment adherence. However, these results should be interpreted with caution. Further research is needed to clarify the relationship between adherence and PIM.

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Cite This Study

Infante-Ventura et al. (2026) studied this question.

synapsesocial.com/papers/69843360f1d9ada3c1fb070dhttps://doi.org/10.1016/j.inpsyc.2026.100189
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