Iris mass associated with anterior uveitis is an uncommon finding and can be of various etiology. This study reports a unique approach to such cases and highlights the role of anti-fungal therapy. A series of three cases of iris mass with anterior uveitis, treated with anti-fungal therapy were retrospectively compiled. The first two cases were initially treated as non-infectious uveitis with corticosteroid, resulting in worsening of symptoms. Despite negative fungal microbiology, they were successfully treated with anti-fungal therapy. The third case with a similar clinical picture, without prior treatment, was effectively treated based on evidence from the other two cases. Any iris mass with uveitis needs proper clinical assessment and workup. Use of steroids, especially systemic, for any intraocular inflammation should be with caution.
Rajbhandari et al. (2026) studied this question.