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February 5, 2026BMC Complementary Medicine and Therapies0 citationsOpen Access

Integrated network pharmacology and bioinformatics analysis reveals MME as key target of Notoginsenoside R1 in diabetic nephropathy

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XGXinyu GanMLMingzhu LiangHSHalinuer Shadekejiang

Key Points

  • The research aims to identify the key molecular target of Notoginsenoside R1 in treating diabetic nephropathy.
  • Conducted network pharmacology analysis to explore drug-target interactions.
  • Utilized bioinformatics tools to assess MME modulation effects.
  • Investigated renoprotective mechanisms related to oxidative stress and inflammation.
  • MME identified as a significant target for Notoginsenoside R1.
  • Notoginsenoside R1 potentially reduces oxidative stress and inflammation.
  • Findings suggest MME's role in mitigating fibrosis in diabetic nephropathy.

Abstract

This study suggests that NGR1 may exert renoprotective effects in DN potentially through MME modulation, which appears to mitigate oxidative stress, inflammation, and fibrosis. The findings indicate MME could serve as a promising therapeutic target, providing preliminary mechanistic insights for developing targeted DN therapies.

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Cite This Study

Gan et al. (2026) studied this question.

synapsesocial.com/papers/69843383f1d9ada3c1fb0bfdhttps://doi.org/10.1186/s12906-026-05272-y
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