The study aims to explore the effects of human milk oligosaccharides on cognitive impairment following traumatic brain injury in mice.
Utilized a mouse model of traumatic brain injury
Administered human milk oligosaccharides
Assessed cognitive performance
Evaluated neuroprotective effects
Human milk oligosaccharides reduced inflammation in the brain
Improved markers of oxidative stress
Enhanced synaptic function
Maintained intestinal barrier integrity
Abstract
HMOs exert neuroprotective effects by targeting central inflammation, oxidative stress, synaptic function, and intestinal barrier integrity, providing a novel natural therapeutic candidate for TBI treatment.