The CD4/CD8 ratio is a pivotal metric in assessing the status of the immune system, crucially implicated in human immunodeficiency virus (HIV) infection dynamics. This review elucidates the multifaceted roles of CD4 and CD8 T cells in immune surveillance and response orchestration. We explore the intricate mechanisms governing their equilibrium and the consequential impact on immune homeostasis. Moreover, we dissect how HIV undermines this delicate balance, precipitating a cascade of immune dysregulation culminating in AIDS progression. Insights into the CD4/CD8 ratio’s prognostic value for disease trajectory and treatment efficacy are discussed, highlighting its potential as a pivotal biomarker in clinical management. Additionally, it interrogates emerging therapeutic modalities leveraging the manipulation of CD4/CD8 ratios as a strategic avenue for HIV intervention. Immunomodulatory agents and gene-based approaches aimed at restoring immune balance hold promise in bolstering host defenses against HIV. By harnessing a deeper understanding of the interplay between CD4 and CD8 T cells, novel therapeutic strategies seek to fortify the immune landscape against HIV-induced immunopathogenesis. This review underscores the significance of CD4/CD8 ratios as not only diagnostic indicators but also as potential targets for therapeutic intervention, heralding new horizons in the battle against HIV/AIDS.
Obeagu et al. (2026) studied this question.