Organophotoredox-Catalyzed Alkylation of Vinylsulfur Pentafluoride: Expanding Access to SF 5 -Containing Aliphatic Molecules

The pentafluorosulfanyl (SF5) group is a valuable fluorinated motif, but aliphatic SF5 synthesis remains challenging. We report a metal-free organophotoredox strategy to access aliphatic SF5 compounds via alkylation of vinylsulfur pentafluoride, prepared from an SF5-triflate precursor. This operationally simple transformation proceeds under mild conditions, tolerates a broad range of functional groups, and affords diverse SF5-substituted alkanes in moderate to good yields. The reaction is amenable to continuous-flow processing.