Compares dementia risk in late-onset and very-late-onset schizophrenia with early-onset schizophrenia, suggesting no increased risk.
Key Points
This research aims to investigate if patients with late-onset schizophrenia (LOS) and very-late-onset schizophrenia-like psychosis (VLOS) have a higher dementia risk than early-onset schizophrenia (EOS) patients.
Analyzed a random sample of schizophrenia cases diagnosed after age 40 (LOS) and age 60 (VLOS).
Conducted systematic reviews of case notes to verify diagnosis and onset age.
Used logistic regression to compare dementia development across groups, controlling for age, gender, and stroke.
Dementia was observed in 10 patients at follow-up.
The proportion with dementia was 6.6% for combined LOS and VLOS groups compared to 4.1% for EOS group.
No statistically significant increase in dementia risk was found for LOS or VLOS compared to EOS.