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February 5, 2026Methods and ProtocolsOpen Access

An Open-Source Automated Pipeline for Quantitative Morphological Analysis of 3D-Bioprinted Cancer Cell Spheroids

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Authors

PAPius N. AmarteyJKJocelyn S. KimYKYetunde I. Kayode

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Overview

Automated pipeline enables quantitative analysis of 3D bioprinted cancer spheroids, suggesting advancements in cancer research methods.

Key Points

  • The aim is to develop an automated pipeline for analyzing 3D bioprinted cancer cell spheroids to enhance cancer research capabilities.
  • Generated 3D spheroid cultures from murine breast cancer cells
  • Utilized GelMA-based bioink and CELLINK BioX bioprinter
  • Followed a detailed protocol for spheroid formation, bioprinting, and analysis
  • Implemented a customized CellProfiler pipeline for post-printing analysis
  • Successfully created reproducible 3D cancer cell spheroids
  • Facilitated high-throughput analysis of spheroid morphology
  • Enabled examination of key cancer research aspects like drug resistance and metastasis

Cite This Study

Amartey et al. (2026) studied this question.

synapsesocial.com/papers/6984345ff1d9ada3c1fb26a0https://doi.org/10.3390/mps9010021
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