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February 5, 2026PLoS neglected tropical diseasesOpen Access

Early vascular toxicity induced by Bothrops atrox venom in the chorioallantoic membrane assay: Kinetic profile and translational insights

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Authors

HKHatem KallelMLMarwa LakhremZBZakaria Boujhoud

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Overview

Demonstrates acute vascular toxicity in a chorioallantoic membrane model, suggesting early antivenom administration is critical.

Key Points

  • To investigate the acute vascular toxicity induced by Bothrops atrox venom using the chicken chorioallantoic membrane model.
  • Exposed fertilized chicken eggs at embryonic day 9 to doses of B. atrox venom (1, 50, and 100 µg/egg)
  • Assessed vascular alterations using macroscopic imaging and quantitative analysis tools
  • Conducted histological examinations to evaluate tissue changes
  • Venom exposure caused dose- and time-dependent vascular disruption
  • At low doses, minimal hemorrhage occurred with no significant changes in vascular architecture
  • High doses resulted in significant endothelial disorganization, vessel dilation, leukocyte infiltration, and microthrombi formation

Cite This Study

Kallel et al. (2026) studied this question.

synapsesocial.com/papers/6984346ff1d9ada3c1fb28c7https://doi.org/10.1371/journal.pntd.0013969
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Urinary proteomics reveals biological processes related to acute kidney injury in Bothrops atrox envenomings2024 · 3 citations
  2. 2Two doses of venom from Bothrops jararaca and Bothrops atrox emitted cytokines and mast cells activation in the peritoneal fluid of C57BL/6 mice 92202025
  3. 3Limited efficacy of cold and heat therapy as adjunctive treatments for local, systemic, and functional outcomes of Bothrops atrox snakebite envenomation: A randomized clinical trial.2025
  4. 4Sex-related differences in toxic manifestations induced by Bothrops atrox venom in mice2024
  5. 5ATYPICAL CASE OF BOTHROPS BILINEATUS SNAKEBITE: THERAPEUTIC FAILURE TO ANTIBOTHROPIC ANTIVENOM AND EXCLUSIVE RESPONSE TO ANTIBOTHROPIC-LACHETIC ANTIVENOM2026