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February 5, 2026Organic Letters

Stereoselective Synthesis of the Western Fragment of Vancoresmycin

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Authors

MSMax SchönenbroicherMSMaximilian SeulSMSimon Morgenschweis

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Overview

This synthesis demonstrates a modular approach to construct complex polyketides, suggesting robust methods for detailed chemical design.

Key Points

  • The aim is to develop a highly stereoselective method for synthesizing the western fragment of vancoresmycin.
  • Employing a modified Cu-catalyzed β-boration protocol
  • Focusing on α,β-unsaturated enones
  • Utilizing convergent construction techniques
  • Achieved high stereocontrol in synthesis
  • Successfully constructed complex polyketide architectures
  • Validated stereochemical assignments through NMR comparison

Cite This Study

Schönenbroicher et al. (2026) studied this question.

synapsesocial.com/papers/6984346ff1d9ada3c1fb2967https://doi.org/10.1021/acs.orglett.6c00073
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