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February 5, 2026SHILAP Revista de lepidopterología0 citationsOpen Access

DNA methylation triage of human papillomavirus-positive atypical squamous cells of undetermined significance in cervical cancer screening

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WXWeiwei XiaYWYì WángXYXiaoxiao Yang

Key Points

  • To evaluate the efficacy of a multigene DNA methylation assay in managing HPV-positive ASC-US in cervical cancer screening.
  • Conducted a DNA methylation assay on samples from HPV-positive ASC-US women.
  • Assessed sensitivity and specificity of the assay.
  • Analyzed the potential to reduce colposcopy referrals.
  • The assay demonstrated high specificity for identifying high-grade lesions.
  • Sensitivity was also good, indicating effective detection in the target population.
  • The method may significantly lower unnecessary colposcopy referrals, especially in women aged ≥30.

Abstract

The host multigene DNA methylation assay demonstrates high specificity and good sensitivity for triaging HPV-positive ASC-US women, with the potential to reduce colposcopy referrals while maintaining robust detection of high-grade lesions, particularly in those aged ≥30 years.

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Cite This Study

Xia et al. (2026) studied this question.

synapsesocial.com/papers/6984346ff1d9ada3c1fb298dhttps://doi.org/10.1080/01443615.2026.2623828
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