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February 5, 2026Applied Psychophysiology and Biofeedback1 citationsOpen Access

Effects of Slow Breathing Exercises on Heart Rate, Blood Pressure, and Quality of Life in Patients Undergoing Primary Percutaneous Coronary Intervention: Randomized Controlled Trial

MÇMelike ÇelikSÇSelda Çelik

Key Result

Slow breathing exercises performed for 8 weeks significantly improved health-related quality of life and reduced heart rate and diastolic blood pressure in patients following primary PCI.

Key Points

  • The research aimed to assess the impact of slow breathing exercises on heart rate, blood pressure, and quality of life in patients undergoing primary PCI.
  • Conducted a randomized controlled trial with patients post-primary PCI.
  • Participants were divided into intervention (slow breathing exercises) and control groups.
  • Intervention group performed exercises twice daily for 10 minutes over 8 weeks.
  • Data collected on heart rate, blood pressure, and quality of life at discharge, 4, and 8 weeks post-discharge.
  • Quality of life significantly improved in the intervention group compared to controls.
  • Heart rate and diastolic blood pressure values decreased after slow breathing exercises.
  • Control group required significantly higher doses of antihypertensive medications.

Study Design

Type

RCT (n=67)

Randomization

Computer-generated block randomization

Multicenter

No

Structured PICO

Do slow breathing exercises improve quality of life and reduce heart rate and blood pressure in hypertensive patients following primary PCI for STEMI?

P
Population
67 adults (18-65 years old) with hypertension and a heart rate > 60 bpm who underwent successful primary percutaneous coronary intervention (PCI) for STEMI at a single hospital in Türkiye. Excluded: patients with arrhythmias, physical limitations/respiratory distress preventing breathing exercises, or diseases raising heart rate.
I
Intervention
Slow breathing exercises (6-8 breaths/minute: inhaling through nostrils for 4 seconds and exhaling through mouth for 6 seconds) performed twice daily for 10 minutes over an 8-week home follow-up period, added to standard medical therapy.
C
Comparator
Standard medical therapy with home monitoring of heart rate and blood pressure (no breathing exercises).
O
Outcome
Heart rate, blood pressure, and quality of life (measured by the MacNew Heart Disease Health-Related Quality of Life Questionnaire) at discharge, and at the 4th and 8th weeks post-discharge.patient reported

A structured 8-week slow breathing exercise program significantly improves quality of life and lowers heart rate and diastolic blood pressure in hypertensive patients recovering from primary PCI for STEMI.

Main Result

Absolute Event Rate: 6.22% vs 5.31%

p-value: p=0.001

Abstract

Abstract This study was conducted to determine the effects of slow breathing exercises performed following primary percutaneous coronary interventions (PCI) on the heart rate, blood pressure, and quality of life of patients. Data were collected from patients admitted to the cardiology inpatient clinic of a hospital in Türkiye after primary PCI between October 2023 and November 2024. Patients were randomly assigned to intervention ( n = 34) and control ( n = 33) groups. The intervention group performed slow breathing exercises twice daily for 10 min over an 8-week home follow-up period. Both groups monitored their heart rate and blood pressure at home during this time. Data were collected using a “Patient Information Form” and the “MacNew Heart Disease Health-Related Quality of Life Questionnaire” at discharge, as well as at the 4th and 8th weeks post-discharge. In all follow-up measurements, the quality of life of the patients in the intervention group was significantly better than that of those in the control group. Throughout the follow-up period, the antihypertensive medication doses of the patients in the control group needed to be increased significantly more. Slow breathing exercises increased the quality of life and reduced the heart rate and diastolic blood pressure values of patients following primary PCI. The exercises led to decreases in heart rate and blood pressure immediately after they were performed. Registry : ClinicalTrials.gov, TRN: NCT06098222, Registration date: 5 October 2023.

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Cite This Study

Çelik et al. (2026) conducted an RCT in ST-Elevation Myocardial Infarction (STEMI) post-primary Percutaneous Coronary Intervention (PCI) (n=67). Slow breathing exercises vs. Standard care was evaluated on MacNew Heart Disease Health-Related Quality of Life Questionnaire total score at 8 weeks (p=0.001). Slow breathing exercises performed for 8 weeks significantly improved health-related quality of life and reduced heart rate and diastolic blood pressure in patients following primary PCI.

synapsesocial.com/papers/6984349af1d9ada3c1fb2ec8https://doi.org/10.1007/s10484-026-09767-9
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