Allosteric ligand–aptamer complexes orchestrate supramolecular or transient catalytic, transcription and fibrinogenesis processes

Key Points

• The aim is to explore how ligand-aptamer interactions enhance the function of DNAzymes and transcription machinery.
• Investigation of allosteric stabilization of DNAzyme and anti-thrombin aptamer.
• Characterization of molecular complexes involving aptamers and catalytic subunits.
• Analysis of transcription processes influenced by ligand-aptamer interactions.
• Ligand/aptamer complexes significantly stabilize the DNAzyme function.
• Enhanced transcriptional activity observed in conditions with allosteric stabilization.
• Increased efficiency in fibrinogenesis processes linked to aptamer-ligand interactions.