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February 5, 2026International Journal of Molecular Sciences0 citationsOpen Access

Inner Potential's Inhibitory Effect on Electroporation of Phospholipid Membranes

Inhibiting Effect of Inner Potential on Electroporation of Phospholipid Membranes Induced by Ionic Electrophoresis

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Authors

PYPing YeHLHaoyang LiKZKuiwen Zhao

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Overview

Molecular dynamics simulations reveal how ion concentration influences electroporation in membranes, indicating critical implications for biomedical therapies.

Key Points

  • This research aims to explore the effects of ion concentration and type on electroporation of phospholipid membranes.
  • Conducted systematic molecular dynamics simulations
  • Manipulated different ion types and concentrations
  • Analyzed the formation of pores in membranes under electrophoretic conditions
  • Examined the relationship between ion concentration and electroporation time
  • Moderate ion concentrations enhance pore formation due to increased ion-membrane interactions
  • High ion concentrations inhibit electroporation by generating an inner potential
  • The inner potential reduces the transmembrane electric field, delaying pore formation
  • A strong correlation exists between ion charge concentration and electroporation time
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Cite This Study

Ye et al. (2026) studied this question.

synapsesocial.com/papers/698434dff1d9ada3c1fb37bahttps://doi.org/10.3390/ijms27031465
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