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February 5, 2026Chemical Science0 citationsOpen Access

Subunit fusion unlocks rapid in vitro maturation for slowly activating heterodimeric FeFe-hydrogenases

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MWMartin Helmut WinklerJJJan JaeneckeKBKonstantin Bikbaev

Key Points

  • This research aims to improve the maturation process of heterodimeric [FeFe]-hydrogenases for efficient H₂ production.
  • Explored subunit fusion techniques to enhance enzyme characteristics.
  • Conducted in vitro experiments with DdHydAB hydrogenase.
  • Analyzed the catalytic efficiency of the modified enzymes.
  • Subunit fusion resulted in a marked increase in maturation speed.
  • Enhanced catalytic performance observed in comparison to non-fused counterparts.
  • The findings suggest potential for wider applications in sustainable energy technologies.

Abstract

Hydrogenases offer a sustainable alternative to noble metals for catalyzing H₂-oxidation and H₂-production. The heterodimeric FeFe-hydrogenase of Desulfovibrio desulfuricans ATCC 7757 (DdHydAB) is most promising due to its exceptional catalytic...

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Cite This Study

Winkler et al. (2026) studied this question.

synapsesocial.com/papers/6984358ff1d9ada3c1fb4882https://doi.org/10.1039/d5sc07299a
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