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February 5, 2026TH OpenOpen Access

Association of fibrin clot characteristics with development of ischemic stroke in patients with recently diagnosed type 2 diabetes

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Authors

NDNicoline DaugaardEBElse-Marie BladbjergHSHelene Matilde Lundsgaard Svane

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Overview

Nested case-control study examines fibrin clot traits in ischemic stroke risk among type 2 diabetes patients, suggesting complex relationships.

Key Points

  • This study investigates the link between fibrin clot characteristics and ischemic stroke risk in patients with type 2 diabetes.
  • Nested case-control study design
  • 144 type 2 diabetes patients with ischemic stroke compared to 144 matched controls
  • Analysis of clot formation, lysis, and structure using turbidimetry
  • Statistical comparisons using Mann Whitney test and conditional logistic regression
  • Fibrin fiber density was lower in future stroke cases compared to controls (p 0.01)
  • Higher Vmax, MA, OHP, and fiber diameter associated with ORs around 1.5 for ischemic stroke
  • Correlation of absolute fibrinogen variant levels with clot characteristics noted, but not relative levels

Cite This Study

Daugaard et al. (2026) studied this question.

synapsesocial.com/papers/698435e5f1d9ada3c1fb536dhttps://doi.org/10.1055/a-2802-3514
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