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February 6, 2026Stem Cell Research & Therapy0 citationsOpen Access

The role of secretome from mesenchymal stromal cells in promoting nerve regeneration after neurotmesis

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YRYaiza González RodríguezASAlejandro Casado SantosMRMaría Rodríguez-Díaz

Key Points

  • This research aims to investigate the effects of mesenchymal stromal cell secretome on nerve regeneration following neurotmesis.
  • Evaluated structural and functional recovery of sciatic nerve after neurotmesis
  • Administered primed MSC secretome
  • Assessed recovery outcomes post-treatment
  • Marked enhancement of nerve regeneration observed
  • Significant improvements in structural and functional recovery
  • Support for the secretome as a cell-free therapy option

Abstract

Primed MSC secretome markedly enhances structural and functional recovery after sciatic nerve neurotmesis, supporting its potential as a safe, effective, and scalable cell-free therapy for peripheral nerve repair.

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Cite This Study

Rodríguez et al. (2026) studied this question.

synapsesocial.com/papers/698584f98f7c464f230083cahttps://doi.org/10.1186/s13287-026-04911-y
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