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February 6, 2026Lab on a Chip0 citations

Microfluidic NMR for Operando Monitoring of Drug-Induced Metabolic Fluxes in Liver Tissue Slices

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SBSylwia Joanna BarkerBPBishnubrata PatraMSManvendra Sharma

Key Points

  • The aim is to develop a platform for real-time monitoring of metabolic changes in liver tissues caused by drugs.
  • Developed the TISuMR platform integrating microfluidics and NMR technology.
  • Utilized liver tissue slices to assess metabolic responses to drug exposure.
  • Ensured continuous and non-invasive monitoring capabilities.
  • Achieved high temporal resolution in detecting metabolic fluxes.
  • Covered a wide range of metabolites, enhancing the understanding of liver metabolism.
  • Demonstrated the platform's effectiveness in operando monitoring of tissue responses.

Abstract

Monitoring metabolism in living tissues with high temporal resolution and broad metabolite coverage remains a major challenge. We introduce the TISuMR platform, a microfluidic Lab-on-a-Chip platform that enables continuous, non-invasive...

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Cite This Study

Barker et al. (2026) studied this question.

synapsesocial.com/papers/698585bd8f7c464f2300958chttps://doi.org/10.1039/d5lc00819k
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