The IL-6 rs1800796 GC/CC genotypes were associated with a lower risk of 5-year MACCE compared to the GG genotype in patients with CAD undergoing PCI (HR 0.810; 95% CI 0.661-0.993; p=0.043).
Cohort (n=4,304)
No
Is the IL-6 rs1800796 G/C polymorphism associated with a reduced risk of MACCE in patients with CAD undergoing PCI?
The IL-6 rs1800796 (G/C) polymorphism is associated with the risk of 5-year MACCE in CAD patients after PCI, suggesting its potential utility for early risk stratification.
Hazard Ratio: 0.81 (95% CI 0.661–0.993)
p-value: p=0.043
Abstract Background Interleukin-6 (IL-6) and IL-6 receptor (IL-6R) gene polymorphisms play an important role in the initiation of coronary artery disease (CAD). However, their link to the poor clinical outcomes of CAD patients remains unknown. The present study was designed to investigate the association between IL-6 and IL-6R gene single nucleotide polymorphisms (SNPs) and long-term major adverse cardiac and cerebrovascular events (MACCE) based on a large-scale (n=10724), observational, single-center, prospective cohort of patients with CAD who underwent percutaneous coronary intervention (PCI). Methods Of 10724, 4304 patients available DNA samples and successfully completed DNA genotyping entered the final analysis. All 4304 subjects were genotyped for IL-6 rs1800796 (G/C), and IL-6R rs4845625 (T/C). The primary endpoint was MACCE, which consists of all-cause death, myocardial infarction, revascularization, and stroke. Univariate and multivariate Cox regression models were employed to analyze the association of the selected SNPs with the risk of MACCE. The hazard ratios (HR) and 95% confidence intervals (CI) were calculated under various genetic models, including dominant, recessive, homozygous, heterozygous, and allelic model. Results After a median follow-up of 5 years, 934 (21.7% ) MACCE occurred. All SNPs conformed to Hardy-Weinberg equilibrium in patients with and without MACCE (P0.05) (Table 1 95% CI=0.661-0.993, p=0.043; GC vs. GG, HR: 0.823; 95% CI=0.680-0.997, p=0.047) (Table 3). No significant association between IL-6R rs4845625 (T/C) and the risk of MACCE. Conclusion The present study reported for the first time that the IL-6 rs1800796 (G/C) functional SNP was associated with risk of 5-year MACCE in patients with PCI, indicating that the detection of IL-6 gene polymorphism could contribute to the early identification of CAD patients at high risk.Hardy-Weinberg Equilibrium Multivariate Cox regression
Li et al. (2025) conducted a cohort in Coronary artery disease (n=4,304). IL-6 rs1800796 GC/CC genotypes vs. IL-6 rs1800796 GG genotype was evaluated on Major adverse cardiac and cerebrovascular events (MACCE: all-cause death, myocardial infarction, revascularization, and stroke) (HR 0.810, 95% CI 0.661-0.993, p=0.043). The IL-6 rs1800796 GC/CC genotypes were associated with a lower risk of 5-year MACCE compared to the GG genotype in patients with CAD undergoing PCI (HR 0.810; 95% CI 0.661-0.993; p=0.043).