Bisalbuminemia is a rare electrophoretic abnormality characterized by two distinct albumin fractions on serum protein electrophoresis 4,5. Although it is most often hereditary, acquired forms may occur in various pathological conditions. Its association with lymphoproliferative disorders and monoclonal gammopathy is uncommon and poorly documented 7. We report the case of a 32-year-old man diagnosed with lymphoma, whose serum protein electrophoresis revealed marked bisalbuminemia associated with an IgG kappa monoclonal spike. Immunotyping confirmed the monoclonal nature of the gamma peak 2,7. Radiological investigations identified multiple lymphadenopathies and secondary neurological involvement. This case highlights the analytical significance of bisalbuminemia in high-resolution electrophoresis and discusses its possible pathophysiological mechanisms in lymphoma 4,6. Awareness of this rare electrophoretic pattern is essential to avoid misinterpretation and ensure accurate detection of clinically significant monoclonal components 2,6.
Hadoui et al. (Sat,) studied this question.