What question did this study set out to answer?

This research aims to understand the emergence and evolutionary dynamics of Salmonella Stanley ST29 carrying the NDM-5 plasmid in a pediatric case.

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February 6, 2026Open Access

Salmonella Stanley ST29 carrying IncHI2/ST3- bla NDM-5 plasmid emerged in a 4-month-old infant with diarrhea

Key Points

This research aims to understand the emergence and evolutionary dynamics of Salmonella Stanley ST29 carrying the NDM-5 plasmid in a pediatric case.
Longitudinal case analysis of a 4-month-old infant with diarrhea.
Sampling of clonal ST29 isolates over a two-month period.
Phylogenomic analysis connecting isolates to community sources.
Discovery of Tn 7051-mediated excision of bla NDM-5 from the IncHI2/ST3 plasmid.
Clonal ST29 isolates showed evolutionary changes over a two-month period.
Phylogenomic connections indicated community dissemination with strains from carriers and food sources.

Abstract

ABSTRACT Salmonella serovar Stanley ST29 is an emerging foodborne pathogen with community spread potential, while its carbapenem resistance remains uncommon. In a longitudinal pediatric case with diarrhea, two clonal ST29 isolates sampled 2 months apart revealed within-host evolutionary dynamics: Tn 7051 -mediated excision of bla NDM-5 from an IncHI2/ST3 plasmid. Moreover, phylogenomics connected the case isolate to strains from a healthy carrier and from food-chain-associated sources in the same region (17–18 SNPs), underscoring community dissemination and the need for One-Health surveillance.

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