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Synapse
February 6, 2026Translational PsychiatryOpen Access

Identifying drug targets for schizophrenia through gene prioritization

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Authors

YLYuhao LinABAlice BraunNBNidhi Banavar

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Overview

Analysis identifies potential drug targets for schizophrenia, highlighting new therapeutic implications.

Key Points

  • The aim is to identify and prioritize genes associated with schizophrenia as potential drug targets.
  • Analyzed a GWAS of 67,390 schizophrenia cases and 94,015 controls.
  • Employed both locus-based methods and genome-wide approaches.
  • Extracted genes targeted by existing drugs and predicted to be druggable.
  • Prioritized 101 genes linked to schizophrenia, including 15 with drug targets.
  • Discovered 7 genes that have not been tested in clinical trials.
  • Identified 2 potentially druggable genes related to both schizophrenia and addiction.

Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/698586118f7c464f23009f28https://doi.org/10.1038/s41398-026-03813-0
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