What question did this study set out to answer?

To investigate the use of NIR-responsive upconversion nanoplatforms and polyoxometalates in amplifying reactive oxygen species to combat beta-amyloid fibrils in Alzheimer’s disease.

February 6, 2026

NIR-Responsive Upconversion Nanoplatforms: an Anionic Drug Carrier for ROS Amplification Induced by β-amyloid Fibrils

Key Points

To investigate the use of NIR-responsive upconversion nanoplatforms and polyoxometalates in amplifying reactive oxygen species to combat beta-amyloid fibrils in Alzheimer’s disease.
Utilized NIR light to activate upconversion nanoplatforms
Applied polyoxometalates as anionic therapeutic agents
Assessed the impact on beta-amyloid fibril depolymerization
Significant amplification of reactive oxygen species observed
Depolymerization of beta-amyloid fibrils enhanced with POM therapy
Potential therapeutic effects on Alzheimer’s disease progression indicated

Abstract

Alzheimer’s disease (AD), marked by the misfolding/aggregation of β-amyloid (Aβ), is a major global health challenge. Polyoxometalates (POMs), as anionic therapeutic agents, exhibit potential in depolymerizing Aβ fibrils, inhibiting Aβ...

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Cite this study

Jia et al. (Thu,) studied this question.

www.synapsesocial.com/papers/698586238f7c464f2300a05e — DOI: https://doi.org/10.1039/d5dt03121d

Authors

Xiaofeng Jia

Yijia Guan

Weijie Cao

Journals

Dalton Transactions

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NIR-Responsive Upconversion Nanoplatforms: an Anionic Drug Carrier for ROS Amplification Induced by β-amyloid Fibrils

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Authors

Journals

Actions

References and Citations

Citation Network

Connected Papers

Discussion