Empagliflozin reduced ventricular arrhythmia episodes (18% vs 28%) and appropriate ICD shocks (14% vs 21%) in heart failure patients with reduced ejection fraction.
Systematic Review
Does empagliflozin reduce ventricular arrhythmias and ICD therapies in heart failure patients with an implantable cardioverter-defibrillator?
463 heart failure patients with reduced ejection fraction (HFrEF) and an implantable cardioverter-defibrillator (ICD) pooled from 4 studies (3 RCTs, 1 retrospective).
Empagliflozin
Control group
Ventricular arrhythmia episodes, appropriate ICD shocks, and anti-tachycardia pacing (ATP) therapyhard clinical
Empagliflozin may provide anti-arrhythmic benefits by significantly reducing ventricular arrhythmias and the need for ICD therapies in patients with HFrEF.
Abstract Background a 22% reduction in late gadolinium enhancement on cardiac MRI, and lower serum biomarkers of myocardial fibrosis, including galectin-3 and ST2 as reported by EMPEROR-Preserved trial. Conclusions Empagliflozin is associated with a lower incidence of ventricular arrhythmias and ICD interventions in HF patients, suggesting a potential anti-arrhythmic benefit. Larger, long-term trials are needed to confirm these findings and elucidate underlying mechanisms.
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Marah Hunjul
M Saad Rakab
K M G Mohammed
European Heart Journal
University of Missouri–Kansas City
University of Toledo
Mansoura University
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Hunjul et al. (Sat,) conducted a systematic review in Heart failure with reduced ejection fraction (HFrEF) and an implantable cardioverter-defibrillator (n=463). Empagliflozin vs. Control was evaluated on Ventricular arrhythmia episodes. Empagliflozin reduced ventricular arrhythmia episodes (18% vs 28%) and appropriate ICD shocks (14% vs 21%) in heart failure patients with reduced ejection fraction.
www.synapsesocial.com/papers/698586388f7c464f2300a324 — DOI: https://doi.org/10.1093/eurheartj/ehaf784.1319