Antifungal secondary metabolites from a mangrove-derived fungus Daldinia eschscholtzii TGM23

One new compound daldiniaone A (1), along with six known compounds 1-(2,6-dihydroxyphenyl)ethan-1-one (2), 1-(2,6-dihydroxyphenyl)butan-1-one (3), penicilliode B (4), (4-hydroxy-3-methoxyphenyl)acetic acid (5), 2-(4-methoxyphenyl)acetic acid (6), and 2-(2-hydroxyethyl)phenol (7), were obtained from the EtOAc extract of the mangrove-derived fungus Daldinia eschscholtzii TGM23. Their structures were characterized by comprehensive spectral analysis, including nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectroscopy (HR-ESI-MS), and electronic circular dichroism (ECD) spectra. All the isolated compounds were tested for their inhibitory activity against three plant pathogenic fungi. Compound 6 showed inhibitory activity against Phytophthora capsici, with the EC50 value of 106.5 μg/ml. Compound 7 exhibited inhibitory activity against Botrytis cinerea with the EC50 value of 86.8 μg/ml.