Testicular ageing as a central hallmark of male senescence: characteristics, molecular mechanisms and emerging therapeutic strategies

Key Points

• The research aims to explore the characteristics and mechanisms of testicular ageing and identify potential therapeutic strategies.
• Examined the structural deterioration in testicular tissues.
• Analyzed the declining steroidogenic and spermatogenic capacities in males.
• Reviewed lifestyle, pharmacological, and stem-cell-based interventions for treating testicular ageing.
• Identified key molecular mechanisms involved in testicular ageing.
• Discussed the limitations of current therapeutic strategies and their clinical applicability.
• Emphasized the need for large-scale studies to validate effective interventions.

Abstract