Association of recent metabolic parameters with macro and mircovascular coronary disease

Abstract Background Cardiovascular diseases still remain one of the most important causes of mortality and morbidity and some new markers are being used to predict them. Visceral adiposity index (VAI), triglyceride-glucose (TyG) index and uric acid are some of these markers. We hypothesized that visceral adiposity index (VAI), triglyceride-glucose (TyG) index and uric acid are associated with obstructive and non-obstructive coronary artery disease and are predictive markers for the development of these diseases. Purpose The objective of this study was to compare visceral adiposity index (VAI), triglyceride-glucose (TyG) index and uric acid levels in patients with obstructive and non-obstructive coronary artery disease. Methods Among 158 consecutive patients who diagnosed as acute coronary syndromes were enrolled. BMI was calculated as body weight in kilograms divided by height in meters squared. WC (waist circumference) was measured at the umbilical level. The VAI score was calculated as described using the following sex-specific equations: Visceral Adiposity Index (VAI) for men: VAI = ( WC / (39.68 + (1.88 × BMI)) ) × ( TG / 1.03 ) × ( 1.31 / HDL ) Visceral Adiposity Index (VAI) for women: VAI = ( WC/(36.58 + (1.89 × BMI)) ) × ( TG/0.81 ) × ( 1.52/HDL ) The TyG index was determined using the formula Ln fasting triglycerides (mg/dL) × fasting plasma glucose (mg (dL)/2. Results A total of 158 people were included in the study; 83 patients were diagnosed with obstructive coronary artery disease and 75 patients were diagnosed with non-obstructive coronary artery disease. Obstructive and non-obstructive coronary artery disease groups were compared in terms of demographic data and the rate of hypertension was statistically significantly more common in the non-obstructive coronary artery disease group. When the present data were compared in terms of laboratory and metabolic parameters, only the visceral adiposity index was statistically significantly higher in patients with non-obstructive coronary artery disease than in patients with obstructive coronary artery disease. Conclusions Visceral adiposity index (VAI), triglyceride-glucose (TyG) index and uric acid levels are known to be associated with epicardial coronary artery disease and acute coronary syndrome, but there are few studies on the importance of these markers in patients presenting with non-obstructive coronary artery disease. In our study, the visceral adiposity index was significantly higher in patients with non-obstructive coronary artery disease than in patients with obstructive coronary artery disease. Based on these findings, the visceral adiposity index may be predictive for the development of ischemia in patients with non-obstructive coronary artery disease and may provide guidance in determining prognosis. Further studies and meta-analyses will shed light on the use of these markers in clinical practice.Patients' characteristics and medication Laboratory values and markers