What question did this study set out to answer?

This research aims to evaluate how thermal preconditioning affects lesion formation in pulsed field ablation.

February 8, 2026Open Access

Thermal preconditioning of targeted tissue enhances pulsed field ablation lesions

DCDaniel Campos-VillarrealBrigham and Women's Hospital MCMaxwell CollBrigham and Women's Hospital LMLogan McClennenBrigham and Women's Hospital

Puntos clave

This research aims to evaluate how thermal preconditioning affects lesion formation in pulsed field ablation.
In vitro model utilized to observe effects of tissue temperature on lesion characteristics.
Tissues subjected to varying temperatures before pulsed field ablation to assess lesions.
Lesion diameter and depth measured post-ablation.
Thermal preconditioning significantly increased lesion diameter and depth.
Higher initial tissue temperatures reduced the electroporation threshold.
These alterations in lesion characteristics imply enhanced efficacy of pulsed field ablation.

Resumen

In this in vitro model, thermal preconditioning significantly alters PFA lesion formation. Increasing the tissue temperature prior to ablation markedly increases lesion diameter and depth, possibly by lowering the electroporation threshold. These findings suggest that tissue temperature is a tunable factor influencing PFA efficacy.

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