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February 8, 2026EJNMMI Research0 citationsOpen Access

Early prognostic stratification of follicular lymphoma through ¹⁸F-FDG PET/CT tumor metabolic parameters and clinical characteristics

SLShao-Chun LiJXJing-Yan XuXFXinyan Fan

Key Points

  • This research aims to identify early predictors of disease progression in follicular lymphoma using imaging and clinical data.
  • Analyzed baseline ¹⁸F-FDG PET/CT imaging for TMTV and DmaxVox metrics.
  • Assessed clinical parameter LDH for its predictive value.
  • Created a predictive model combining imaging and clinical parameters to stratify risk.
  • TMTV and DmaxVox are independent predictors of early disease progression within 24 months.
  • LDH levels also serve as a significant risk indicator.
  • The predictive model effectively categorizes patient risk based on these metrics.

Abstract

TMTV and DmaxVox on baseline 18F-FDG PET/CT imaging, along with the clinical parameter LDH, are independent predictors of early disease progression within 24 months (POD24) in patients with FL. A predictive model combining these imaging metrics with clinical parameters effectively stratifies patient risk.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/698827570fc35cd7a8845fe9https://doi.org/10.1186/s13550-026-01384-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Baseline PSMA PET/CT parameters predict overall survival and treatment response in metastatic castration-resistant prostate cancer patients2025 · 14 citations
  2. 2Combining Total Metabolic Tumor Volume With Beta‐2‐Microglobulin Levels Predicts Outcomes in High‐Burden Follicular Lymphoma Patients2024 · 4 citations
  3. 3Combined PET and ctDNA response as a predictor of POD24 for follicular lymphoma after first-line induction treatment2025 · 14 citations
  4. 4A machine learning-based model to predict POD24 in follicular lymphoma: a study by the Chinese workshop on follicular lymphoma2025 · 8 citations
  5. 5The prognostic index PRIMA-PI combined with Ki67 as a better predictor of progression of disease within 24 months in follicular lymphoma2023 · 7 citations