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February 8, 2026European Heart Journal

Higher peak VO2 strongly correlates with better QoL and less depression in hypertensive obese patients.

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Why the study?

Exercise intolerance is typical in hypertensive heart disease and tied to poor outcomes, but the impact of exercise capacity on quality-of-life and mental stress in obese patients with essential hypertension required prospective evaluation.

Population

87 patients with essential hypertension without coronary artery disease

Comparison

Exercise capacity via CPET compared across obesity and BMI levels

Design

Prospective study

Key result

In hypertensive obese patients, peakVO2 correlated positively with QoL (r=0.55) and negatively with depression severity (r=-0.78), indicating exercise capacity strongly affects mental health and QoL.

Authors

EKEmmanouil KampanierisIKI KommatasPKPetros Kalomoirakis

Discussion

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Overview

Should not yet change practice in obese hypertension; extends observational data but remains hypothesis-generating.

Key Points

  • Evaluate the relationship between exercise capacity and quality of life and mental stress in obese patients with essential hypertension.
  • Included 87 obese patients with essential hypertension.
  • Performed cardiopulmonary exercise testing (CPET) to measure exercise capacity.
  • Assessed quality of life using the SF-12 questionnaire and mental health with the PHQ-9 instrument.
  • Analyzed correlations between exercise capacity, quality of life, and mental health indicators.
  • Mean exercise duration was 8.5 minutes; peak oxygen uptake was 17.4 mL/kg/min.
  • Obese patients showed significantly lower exercise capacity compared to non-obese individuals (p < 0.001).
  • High body mass index correlated with lower SF-12 scores and higher PHQ-9 scores (p < 0.001).
  • Peak oxygen uptake was significantly correlated with quality of life (r = 0.55, p < 0.001) and negatively correlated with depression scores (r = -0.78, p < 0.001).

Structured PICO

P
Population
87 patients with essential hypertension without coronary artery disease (mean age 69, 57 male), including 67 obese patients, 50 with diabetes, and 39 with heart failure with preserved ejection fraction.
I
Intervention
Assessment of exercise capacity via cardiopulmonary exercise testing (CPET)
O
Outcome
Quality of life evaluated by the 12-item Medical Outcome Study Short Form Health Survey Questionnaire (SF-12) and depressive symptoms evaluated by the Patient Health Questionnaire-9 (PHQ-9)patient reported

In patients with essential hypertension, lower exercise capacity is strongly correlated with worse quality of life and higher depressive symptoms, particularly in those with obesity.

Cite This Study

Kampanieris et al. (2025) studied this question. In hypertensive obese patients, peakVO2 correlated positively with QoL (r=0.55) and negatively with depression severity (r=-0.78), indicating exercise capacity strongly affects mental health and QoL.

synapsesocial.com/papers/698827570fc35cd7a884608dhttps://doi.org/10.1093/eurheartj/ehaf784.3854
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