Microplastics were detected in the septum of 40% of canines after left bundle branch pacing, with particles averaging 81750 μm² and surrounded by inflammatory cells.
Does left bundle branch pacing (LBBP) implantation lead to the deposition of microplastics in the septum in a canine model?
This preclinical study provides the first evidence that left bundle branch pacing implantation can introduce microplastics into the cardiac septum, potentially causing local inflammation.
Abstract Background and Objective Microplastics (MPs) pose a significant health risk due to their pervasive presence and potential adverse effects. left bundle branch pacing (LBBP) is a novel physiological pacing modality, which characteristics with deep fixation of the lead into the septum. Whether MPs could be detected or not in septum after LBBP is unknown. Methods Ten beagles were selected to receive LBBP implantation. The C315 Sheath with the SelectSecure pacing lead (Model 3830) were used for LBBP. After 6 weeks follow-up, the animals were killed and the septum were taken and analyzed using Hematoxylin-Eosin staining approach. Results MPs was detected in septum of four LBBP canines (40.0%), with a mean maximum cross-sectional area of 81750 ± 8655.4 μm2. The mean distance between MPs and the septal cavity by LBBP lead was 522.5 ± 75.9μm. All MPs were surrounded by inflammatory cells. Conclusions Our study for the first time demonstrated that MPs could be detected in canine septum after LBBP implantation. This promising pacing modality may be a new route for MPs to enter the human body.Hematoxylin-Eosin staining in a canine
Hu et al. (2025) studied this question. Microplastics were detected in the septum of 40% of canines after left bundle branch pacing, with particles averaging 81750 μm² and surrounded by inflammatory cells.