Impact of protein corona morphology on nanoparticle diffusion in biological fluids: insights from a mesoscale approach.

Key Points

• This research aims to understand how the shape and structure of a protein corona around nanoparticles affect their movement in biological environments.
• Conducted mesoscale simulations of nanoparticle diffusion in biological fluids
• Analyzed protein corona morphology on nanoparticles
• Examined the effect of different protein types on diffusion rates
• Identified distinct diffusion patterns influenced by protein shape
• Showed that certain protein coronas enhance nanoparticle movement
• Found that diverse proteins can either hinder or facilitate diffusion