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February 8, 2026FEBS Journal0 citationsOpen Access

Harnessing S. cerevisiae to advance the engineering of pentatricopeptide repeat proteins

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FGFarley M. Kwok van der GiezenISIan Small

Key Points

  • The aim is to explore how yeast can facilitate the study and engineering of plant RNA editing proteins and pentatricopeptide repeat proteins.
  • Discussion of existing literature on yeast as a model for plant RNA editing.
  • Analysis of the potential contributions of pentatricopeptide repeat proteins to yeast engineering.
  • The establishment of yeast as a model system enhances understanding of RNA editing.
  • Pentatricopeptide repeat proteins can be engineered to improve yeast functions.

Abstract

Heterologous expression systems have been instrumental in furthering our understanding of plant RNA editing proteins. In this commentary, we discuss how the establishment of yeast as a model for studying plant RNA editing by Ramanathan et al. could advance the engineering of pentatricopeptide repeat proteins, and how in return pentatricopeptide repeat proteins might be used to advance yeast engineering.

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Cite This Study

Giezen et al. (2026) studied this question.

synapsesocial.com/papers/6988278b0fc35cd7a8846642https://doi.org/10.1111/febs.70438
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