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February 8, 2026BMC Medicine0 citationsOpen Access

Genetic risk factors modulate the association between physical activity and colorectal cancer

APAnita R. PeoplesMOMireia Obón-SantacanaAKAndre E. Kim

Key Points

  • The research aims to explore how genetic variants affect the relationship between physical activity and colorectal cancer risk.
  • Identified genetic variants associated with colorectal cancer risk.
  • Analyzed the interaction between physical activity levels and genetic variants.
  • Assessed the roles of BMP-related, inflammatory, and insulin signaling pathways.
  • Two genetic variants were found to modify the association between physical activity and colorectal cancer risk.
  • The GREM1 and SCG5 variants indicate a potential involvement of BMP pathways in cancer protection.

Abstract

In summary, we identified two genetic variants that modified the association between physical activity and CRC risk. One of them, related to GREM1 and SCG5, suggests that the bone morphogenetic protein (BMP)-related, inflammatory, and/or insulin signaling pathways may be involved in the protective association between physical activity and colorectal carcinogenesis.

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Cite This Study

Peoples et al. (2026) studied this question.

synapsesocial.com/papers/6988278b0fc35cd7a884666fhttps://doi.org/10.1186/s12916-026-04675-5
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